Ontology highlight
ABSTRACT:
SUBMITTER: Iachettini S
PROVIDER: S-EPMC6155207 | biostudies-literature | 2018 Sep
REPOSITORIES: biostudies-literature
Iachettini Sara S Trisciuoglio Daniela D Rotili Dante D Lucidi Alessia A Salvati Erica E Zizza Pasquale P Di Leo Luca L Del Bufalo Donatella D Ciriolo Maria Rosa MR Leonetti Carlo C Steegborn Clemens C Mai Antonello A Rizzo Angela A Biroccio Annamaria A
Cell death & disease 20180924 10
Sirtuin 6 (SIRT6) is a member of the NAD<sup>+</sup>-dependent class III deacetylase sirtuin family, which plays a key role in cancer by controlling transcription, genome stability, telomere integrity, DNA repair, and autophagy. Here we analyzed the molecular and biological effects of UBCS039, the first synthetic SIRT6 activator. Our data demonstrated that UBCS039 induced a time-dependent activation of autophagy in several human tumor cell lines, as evaluated by increased content of the lipidate ...[more]