Synthesis of Randomly Substituted Anionic Cyclodextrins in Ball Milling.

ABSTRACT: A number of influencing factors mean that the random substitution of cyclodextrins (CD) in solution is difficult to reproduce. Reaction assembly in mechanochemistry reduces the number of these factors. However, lack of water can improve the reaction outcomes by minimizing the reagent's hydrolysis. High-energy ball milling is an efficient, green and simple method for one-step reactions and usually reduces degradation and byproduct formation. Anionic CD derivatives have successfully been synthesized in the solid state, using a planetary ball mill. Comparison with solution reactions, the solvent-free conditions strongly reduced the reagent hydrolysis and resulted in products of higher degree of substitution (DS) with more homogeneous DS distribution. The synthesis of anionic CD derivatives ca

SUBMITTER: Jicsinszky L 

PROVIDER: S-EPMC6155213 | biostudies-literature | 2017 Mar

REPOSITORIES: biostudies-literature