Ontology highlight
ABSTRACT:
SUBMITTER: Gustafsson NMS
PROVIDER: S-EPMC6155239 | biostudies-literature | 2018 Sep
REPOSITORIES: biostudies-literature
Gustafsson Nina M S NMS Färnegårdh Katarina K Bonagas Nadilly N Ninou Anna Huguet AH Groth Petra P Wiita Elisee E Jönsson Mattias M Hallberg Kenth K Lehto Jemina J Pennisi Rosa R Martinsson Jessica J Norström Carina C Hollers Jessica J Schultz Johan J Andersson Martin M Markova Natalia N Marttila Petra P Kim Baek B Norin Martin M Olin Thomas T Helleday Thomas T
Nature communications 20180924 1
The glycolytic PFKFB3 enzyme is widely overexpressed in cancer cells and an emerging anti-cancer target. Here, we identify PFKFB3 as a critical factor in homologous recombination (HR) repair of DNA double-strand breaks. PFKFB3 rapidly relocates into ionizing radiation (IR)-induced nuclear foci in an MRN-ATM-γH2AX-MDC1-dependent manner and co-localizes with DNA damage and HR repair proteins. PFKFB3 relocalization is critical for recruitment of HR proteins, HR activity, and cell survival upon IR. ...[more]