Ontology highlight
ABSTRACT:
SUBMITTER: Vattulainen-Collanus S
PROVIDER: S-EPMC6155317 | biostudies-literature | 2018
REPOSITORIES: biostudies-literature
Communications biology 20180924
The integrity of blood vessels is fundamental to vascular homeostasis. Inactivating mutations in the bone morphogenetic protein (BMP) receptor type II (BMPR2) gene cause hereditary vascular disorders, including pulmonary arterial hypertension and hereditary hemorrhagic telangiectasia, suggesting that BMPR2 and its downstream signaling pathway are pivotal to the maintenance of vascular integrity through an unknown molecular mechanism. Here we report that inactivation of BMPR2 in pulmonary vascula ...[more]