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ABSTRACT:
SUBMITTER: Liu Q
PROVIDER: S-EPMC6155393 | biostudies-literature | 2017 Mar
REPOSITORIES: biostudies-literature
Liu Qiaoyun Q Wang Jing J Li Junfei J Wang Xiaolei X Lu Shichao S Li Xuan X Gong Yaling Y Xu Shu S
Molecules (Basel, Switzerland) 20170320 3
Separation of the enantiomers of new chiral alkynes in strategic syntheses and bioorthogonal studies is always problematic. The chiral column high-performance liquid chromatography (HPLC) method in general could not be directly used to resolve such substrates, since the differentiation of the alkyne segment with the other alkane/alkene segment is not significant in the stationary phase, and the alkyne group is not a good UV chromophore. Usually, a pre-column derivatization reaction with a tediou ...[more]