Ontology highlight
ABSTRACT:
SUBMITTER: Alarcon F
PROVIDER: S-EPMC6155453 | biostudies-literature | 2018
REPOSITORIES: biostudies-literature
Alarcon Flora F Planté-Bordeneuve Violaine V Olsson Malin M Nuel Grégory G
PloS one 20180925 9
In genetic diseases with variable age of onset, survival function estimation for the mutation carriers as well as estimation of the modifying factors effects are essential to provide individual risk assessment, both for mutation carriers management and prevention strategies. In practice, this survival function is classically estimated from pedigrees data where most genotypes are unobserved. In this article, we present a unifying Expectation-Maximization (EM) framework combining probabilistic com ...[more]