Ontology highlight
ABSTRACT:
SUBMITTER: Meirer K
PROVIDER: S-EPMC6155600 | biostudies-literature | 2016 Dec
REPOSITORIES: biostudies-literature
Meirer Karin K Glatzel Daniel D Kretschmer Simon S Wittmann Sandra K SK Hartmann Markus M Blöcher René R Angioni Carlo C Geisslinger Gerd G Steinhilber Dieter D Hofmann Bettina B Fürst Robert R Proschak Ewgenij E
Molecules (Basel, Switzerland) 20161229 1
The arachidonic acid cascade is a key player in inflammation, and numerous well-established drugs interfere with this pathway. Previous studies have suggested that simultaneous inhibition of 5-lipoxygenase (5-LO) and soluble epoxide hydrolase (sEH) results in synergistic anti-inflammatory effects. In this study, a novel prototype of a dual 5-LO/sEH inhibitor <b>KM55</b> was rationally designed and synthesized. <b>KM55</b> was evaluated in enzyme activity assays with recombinant enzymes. Furtherm ...[more]