Ontology highlight
ABSTRACT:
SUBMITTER: Wang DM
PROVIDER: S-EPMC6155837 | biostudies-literature | 2017 Jan
REPOSITORIES: biostudies-literature
Wang Dong-Mei DM Feng Bo B Fu Hui H Liu Ai-Lin AL Wang Lin L Du Guan-Hua GH Wu Song S
Molecules (Basel, Switzerland) 20170120 1
Alzheimer's disease (AD), the most common form of dementia in adults, is a progressive neurodegenerative disorder of the brain characterized by loss of memory and steady deterioration of cognition. Here, a series of symmetrical molecules containing biphenyl/bibenzyl scaffolds (<b>12</b>-<b>36</b>) were designed, synthesized, and evaluated for their ability to inhibit both acetylcholinesterase (AChE) and butyrylcholinesterase (BuChE). A biological evaluation showed that most of these biphenyl der ...[more]