Ontology highlight
ABSTRACT:
SUBMITTER: Zhu J
PROVIDER: S-EPMC6156150 | biostudies-literature | 2018
REPOSITORIES: biostudies-literature
Zhu Junyu J Luo Li L Tian Lixing L Yin Shangqi S Ma Xiaoyuan X Cheng Shaowen S Tang Wanqi W Yu Jing J Ma Wei W Zhou Xiaoying X Fan Xia X Yang Xue X Yan Jun J Xu Xiang X Lv Chuanzhu C Liang Huaping H
Frontiers in immunology 20180919
The aryl hydrocarbon receptor (AhR) is an important immune regulator with a role in inflammatory response. However, the role of AhR in IL-10 production by inflammatory macrophages is currently unknown. In this study, we investigated LPS-induced IL-10 expression in macrophages from AhR-KO mice and AhR-overexpressing RAW264.7 cells. AhR was highly expressed after LPS stimulation through NF-κB pathway. Loss of AhR resulted in reduced IL-10 expression in LPS-induced macrophages. Moreover, the IL-10 ...[more]