Unknown

Dataset Information

0

A polymorphism in the fatty acid desaturase-2 gene is associated with the arachidonic acid metabolism in pigs.


ABSTRACT: Arachidonic acid (C20:4) is related to a wide range of biological effects including lipid homeostasis. The fatty acid desaturase-2 (FADS2) gene encodes for the delta-6-desaturase, which is involved in the biosynthesis of C20:4 from linoleic acid (C18:2). The purpose of this study was to characterise mutations in the promoter of the porcine FADS2, evaluating in particular the effect of one haplotype tagging polymorphism (rs321384923A?>?G) on the biosynthesis pathway of C20:4. A total of 1,192 Duroc barrows with records on fatty acid composition in muscle and subcutaneous fat were genotyped. Pigs carrying the A allele showed, irrespective of fat content, both enhanced FADS2 expression and higher C20:4 in muscle and exhibited increased ratios of C20:4 to C18:2 and of C20:4 to eicosadienoic acid (C20:2) in both muscle and adipose tissue. Despite the inverse relationship observed between C20:4 and fat content, the rs321384923 polymorphism had no impact on lean weight. It is concluded that the haplotype encompassing the rs321384923 polymorphism at the porcine FADS2 affects the n-6 fatty acid profile by specifically modifying the desaturation efficiency of C18:2 to C20:4 rather than by concomitant variations in C18:2 following changes in fat content.

SUBMITTER: Gol S 

PROVIDER: S-EPMC6156218 | biostudies-literature | 2018 Sep

REPOSITORIES: biostudies-literature

altmetric image

Publications

A polymorphism in the fatty acid desaturase-2 gene is associated with the arachidonic acid metabolism in pigs.

Gol Sofia S   Pena Ramona N RN   Rothschild Max F MF   Tor Marc M   Estany Joan J  

Scientific reports 20180925 1


Arachidonic acid (C20:4) is related to a wide range of biological effects including lipid homeostasis. The fatty acid desaturase-2 (FADS2) gene encodes for the delta-6-desaturase, which is involved in the biosynthesis of C20:4 from linoleic acid (C18:2). The purpose of this study was to characterise mutations in the promoter of the porcine FADS2, evaluating in particular the effect of one haplotype tagging polymorphism (rs321384923A > G) on the biosynthesis pathway of C20:4. A total of 1,192 Dur  ...[more]

Similar Datasets

| S-EPMC404050 | biostudies-literature
| S-EPMC3544903 | biostudies-literature
| S-EPMC3494092 | biostudies-literature
2018-05-23 | GSE93102 | GEO
| S-EPMC6036782 | biostudies-literature
| S-EPMC6115977 | biostudies-literature
| S-EPMC6394981 | biostudies-literature
| S-EPMC5958418 | biostudies-literature
| S-EPMC7339922 | biostudies-literature
| S-EPMC4280302 | biostudies-literature