Ontology highlight
ABSTRACT:
SUBMITTER: Jiang WY
PROVIDER: S-EPMC6156357 | biostudies-literature | 2018 Oct
REPOSITORIES: biostudies-literature
Jiang Wen-Yan WY Xing Chun C Wang Hong-Wei HW Wang Wei W Chen Su-Zhen SZ Ning Liu-Fang LF Xu Xu X Tang Qi-Qun QQ Huang Hai-Yan HY
Journal of cellular and molecular medicine 20180725 10
Accelerated marrow adipogenesis has been associated with ageing and osteoporosis and is thought to be because of an imbalance between adipogenic and osteogenic differentiation of mesenchymal stem cell (MSCs). We have previously found that lysyl oxidase (Lox) inhibition disrupts BMP4-induced adipocytic lineage commitment and differentiation of MSCs. In this study, we found that lox inhibition dramatically up-regulates BMP4-induced expression of CCAAT/enhancer binding protein (C/EBP) homologous pr ...[more]