Ontology highlight
ABSTRACT:
SUBMITTER: Meng Q
PROVIDER: S-EPMC6156365 | biostudies-literature | 2018
REPOSITORIES: biostudies-literature
Meng Qingda Q Valentini Davide D Rao Martin M Maeurer Markus M
Frontiers in oncology 20180919
KRAS is a driver mutation for malignant transformation. It is found in 30% of all cancers and in 90% of pancreatic cancers. The identification of small molecules selectively inhibiting KRAS mutants has been challenging, yet mutant KRAS has recently been shown to be targeted by tumor-infiltrating lymphocyte (TIL)-derived T cells that confer tumor regression upon adoptive transfer. Furthermore, a human IgG1 monoclonal antibody interfering with mutant KRAS function inside the cell has been describe ...[more]