Ontology highlight
ABSTRACT:
SUBMITTER: Rehkamp A
PROVIDER: S-EPMC6156451 | biostudies-literature | 2018
REPOSITORIES: biostudies-literature
Rehkamp Anne A Tänzler Dirk D Iacobucci Claudio C Golbik Ralph P RP Ihling Christian H CH Sinz Andrea A
Frontiers in molecular neuroscience 20180919
The rod outer segment guanylyl cyclase 1 (ROS-GC1) is an essential component of photo-transduction in the retina. In the light-induced signal cascade, membrane-bound ROS-GC1 restores cGMP levels in the dark in a calcium-dependent manner. With decreasing calcium concentration in the intracellular compartment, ROS-GC1 is activated via the intracellular site by guanylyl cyclase-activating proteins (GCAP-1/-2). Presently, the exact activation mechanism is elusive. To obtain structural insights into ...[more]