Ontology highlight
ABSTRACT:
SUBMITTER: Alvarez-Garcia O
PROVIDER: S-EPMC6156454 | biostudies-literature | 2018 Oct
REPOSITORIES: biostudies-literature
Alvarez-Garcia Oscar O Matsuzaki Tokio T Olmer Merissa M Miyata Kohei K Mokuda Sho S Sakai Daisuke D Masuda Koichi K Asahara Hiroshi H Lotz Martin K MK
Aging cell 20180702 5
Intervertebral disk (IVD) degeneration is a prevalent age-associated musculoskeletal disorder and a major cause of chronic low back pain. Aging is the main risk factor for the disease, but the molecular mechanisms regulating IVD homeostasis during aging are unknown. The aim of this study was to investigate the function of FOXO, a family of transcription factors linked to aging and longevity, in IVD aging and age-related degeneration. Conditional deletion of all FOXO isoforms (FOXO1, 3, and 4) in ...[more]