Ontology highlight
ABSTRACT:
SUBMITTER: Jiang K
PROVIDER: S-EPMC6156511 | biostudies-literature | 2018 Sep
REPOSITORIES: biostudies-literature
Jiang Kewu K Tang Zan Z Li Juan J Wang Fengchao F Tang Nan N
Scientific reports 20180925 1
Genetic studies have shown that FGF10/FGFR2 signaling is required for airway branching morphogenesis and FGF10 functions as a chemoattractant factor for distal epithelial cells during lung development. However, the detail downstream cellular and molecular mechanisms have not been fully characterized. Using live imaging of ex vivo cultured lungs, we found that tip airway epithelial progenitor cells migrate faster than cleft cells during airway bud formation and this migration process is controlle ...[more]