RNA editing derived epitopes function as cancer antigens to elicit immune responses.
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ABSTRACT:
SUBMITTER: Zhang M
PROVIDER: S-EPMC6156571 | biostudies-literature | 2018 Sep
REPOSITORIES: biostudies-literature
Publications
RNA editing derived epitopes function as cancer antigens to elicit immune responses.
Zhang Minying M Fritsche Jens J Roszik Jason J Williams Leila J LJ Peng Xinxin X Chiu Yulun Y Tsou Chih-Chiang CC Hoffgaard Franziska F Goldfinger Valentina V Schoor Oliver O Talukder Amjad A Forget Marie A MA Haymaker Cara C Bernatchez Chantale C Han Leng L Tsang Yiu-Huen YH Kong Kathleen K Xu Xiaoyan X Scott Kenneth L KL Singh-Jasuja Harpreet H Lizee Greg G Liang Han H Weinschenk Toni T Mills Gordon B GB Hwu Patrick P
Nature communications 20180925 1
In addition to genomic mutations, RNA editing is another major mechanism creating sequence variations in proteins by introducing nucleotide changes in mRNA sequences. Deregulated RNA editing contributes to different types of human diseases, including cancers. Here we report that peptides generated as a consequence of RNA editing are indeed naturally presented by human leukocyte antigen (HLA) molecules. We provide evidence that effector CD8<sup>+</sup> T cells specific for edited peptides derived ...[more]
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