Ontology highlight
ABSTRACT:
SUBMITTER: Antoury L
PROVIDER: S-EPMC6156576 | biostudies-literature | 2018 Sep
REPOSITORIES: biostudies-literature
Antoury Layal L Hu Ningyan N Balaj Leonora L Das Sudeshna S Georghiou Sofia S Darras Basil B Clark Tim T Breakefield Xandra O XO Wheeler Thurman M TM
Nature communications 20180925 1
Urine contains extracellular RNA (exRNA) markers of urogenital cancers. However, the capacity of genetic material in urine to identify systemic diseases is unknown. Here we describe exRNA splice products in human urine as a source of biomarkers for the two most common forms of muscular dystrophies, myotonic dystrophy (DM) and Duchenne muscular dystrophy (DMD). Using a training set, RT-PCR, droplet digital PCR, and principal component regression, we identify ten transcripts that are spliced diffe ...[more]