Ontology highlight
ABSTRACT:
SUBMITTER: Byrnes LE
PROVIDER: S-EPMC6156586 | biostudies-literature | 2018 Sep
REPOSITORIES: biostudies-literature
Byrnes Lauren E LE Wong Daniel M DM Subramaniam Meena M Meyer Nathaniel P NP Gilchrist Caroline L CL Knox Sarah M SM Tward Aaron D AD Ye Chun J CJ Sneddon Julie B JB
Nature communications 20180925 1
Organogenesis requires the complex interactions of multiple cell lineages that coordinate their expansion, differentiation, and maturation over time. Here, we profile the cell types within the epithelial and mesenchymal compartments of the murine pancreas across developmental time using a combination of single-cell RNA sequencing, immunofluorescence, in situ hybridization, and genetic lineage tracing. We identify previously underappreciated cellular heterogeneity of the developing mesenchyme and ...[more]