Ontology highlight
ABSTRACT:
SUBMITTER: Fu Q
PROVIDER: S-EPMC6156635 | biostudies-literature | 2018 Sep
REPOSITORIES: biostudies-literature
Fu Qingshan Q Shaik Md Munan MM Cai Yongfei Y Ghantous Fadi F Piai Alessandro A Peng Hanqin H Rits-Volloch Sophia S Liu Zhijun Z Harrison Stephen C SC Seaman Michael S MS Chen Bing B Chou James J JJ
Proceedings of the National Academy of Sciences of the United States of America 20180905 38
The membrane-proximal external region (MPER) of the HIV-1 envelope glycoprotein (Env) bears epitopes of broadly neutralizing antibodies (bnAbs) from infected individuals; it is thus a potential vaccine target. We report an NMR structure of the MPER and its adjacent transmembrane domain in bicelles that mimic a lipid-bilayer membrane. The MPER lies largely outside the lipid bilayer. It folds into a threefold cluster, stabilized mainly by conserved hydrophobic residues and potentially by interacti ...[more]