Dataset Information

A U-shaped relationship of body mass index on atrial fibrillation recurrence post ablation: A report from the Guangzhou atrial fibrillation ablation registry.

ABSTRACT:

Background

Obesity or overweight is related to worse outcomes in patients with atrial fibrillation (AF) following catheter ablation (CA). The role of being underweight in relation to recurrent arrhythmias post AF ablation is less certain. We conducted a retrospective study to investigate the association of body mass index (BMI) with arrhythmia outcomes in AF patients undergoing CA.

Methods

In a cohort of 1410 AF patients (mean age 57.2?±?11.6?years; 68% male) undergoing single CA, the association between BMI and AF ablation outcome was analyzed using BMI as a continuous variable and by four BMI categories (<18.5?kg/m², 18.5-24?kg/m², 25-29?kg/m², and???30?kg/m²).

Result

We observed a positive association between a cut off value of BMI and risk of AF recurrence post AF ablation. BMI ?26.36?kg/m² was related to more AF recurrence (c-statistic 0.55, 95%CI 0.51-0.58; P?2 and???30?kg/m² were all associated with more AF recurrence (P?=?0.01). Both underweight (HR 1.85, 95%CI 1.12-3.08; P?=?0.02) and obesity (HR 1.78, 95%CI 1.17-2.72; P?=?0.01) significantly increased the risk of AF recurrence in a Cox proportional hazard model.

Conclusion

BMI had good predictive value for AF ablation outcomes with a cut off value of ?26.36?kg/m². Apart from being obese/overweight, being underweight might also be a risk factor for AF recurrence post ablation.

SUBMITTER: Deng H

PROVIDER: S-EPMC6156736 | biostudies-literature | 2018 Sep

REPOSITORIES: biostudies-literature

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Publications

A U-shaped relationship of body mass index on atrial fibrillation recurrence post ablation: A report from the Guangzhou atrial fibrillation ablation registry.

Deng Hai H Shantsila Alena A Guo Pi P Potpara Tatjana S TS Zhan Xianzhang X Fang Xianhong X Liao Hongtao H Liu Yang Y Wei Wei W Fu Lu L Wu Shulin S Xue Yumei Y Lip Gregory Y H GYH

EBioMedicine 20180830

<h4>Background</h4>Obesity or overweight is related to worse outcomes in patients with atrial fibrillation (AF) following catheter ablation (CA). The role of being underweight in relation to recurrent arrhythmias post AF ablation is less certain. We conducted a retrospective study to investigate the association of body mass index (BMI) with arrhythmia outcomes in AF patients undergoing CA.<h4>Methods</h4>In a cohort of 1410 AF patients (mean age 57.2 ± 11.6 years; 68% male) undergoing single CA, ...[more]

PMID: 30174278

Similar Datasets

Project description:ObjectivesThe incidence of atrial fibrillation (AF) in patients older than 75 years of age is expected to increase, and its treatment remains challenging. This study evaluated the impact of age on the outcomes of surgical ablation of AF.MethodsA retrospective review was performed of patients who underwent the Cox-maze IV procedure at a single institution between 2005 and 2017. The patients were divided into a younger (age <75 years, n = 548) and an elderly cohort (age ≥75 years, n = 148). Rhythm outcomes were assessed at 1 year and annually thereafter. Predictors of first atrial tachyarrhythmia (ATA) recurrence were determined using Fine-Gray regression, allowing for death as the competing risk.ResultsThe mean age of the elderly group was 78.5 ± 2.8 years. The majority of patients (423/696, 61%) had nonparoxysmal AF. The elderly patients had a lower body mass index (P < .001) and greater rates of hypertension (P = .011), previous myocardial infarction (P = .017), heart failure (P < .001), and preoperative pacemaker (P = .008). Postoperatively, the elderly group had a greater rate of overall major complications (23% vs 14%, P = .017) and 30-day mortality (6% vs 2%, P = .026). The percent freedom from ATAs and antiarrhythmic drugs was lower in the elderly patients at 3 (69% vs 82%, P = .030) and 4 years (65% vs 79%, P = .043). By competing risk analysis, the incidence of first ATA recurrence was greater in elderly patients (33% vs 20% at 5 years; Gray test, P = .005). On Fine-Gray regression adjusted for clinically relevant covariates, increasing age was identified as a predictor of ATAs recurrence (subdistribution hazard ratio, 1.03; 95% confidence interval, 1.02-1.05, P < .001).ConclusionsThe efficacy of the Cox-maze IV procedure was worse in elderly patients; however, the majority of patients remained free of ATAs at 5 years. The lower success rate in these greater-risk patients should be considered when deciding to perform surgical ablation.

Dataset Information

A U-shaped relationship of body mass index on atrial fibrillation recurrence post ablation: A report from the Guangzhou atrial fibrillation ablation registry.

Background

Methods

Result

Conclusion

Publications

A U-shaped relationship of body mass index on atrial fibrillation recurrence post ablation: A report from the Guangzhou atrial fibrillation ablation registry.

Similar Datasets

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