Ontology highlight
ABSTRACT:
SUBMITTER: Graham DB
PROVIDER: S-EPMC6156773 | biostudies-literature | 2018 Jul
REPOSITORIES: biostudies-literature
Graham Daniel B DB Jasso Guadalupe J GJ Mok Amanda A Goel Gautam G Ng Aylwin C Y ACY Kolde Raivo R Varma Mukund M Doench John G JG Root David E DE Clish Clary B CB Carr Steven A SA Xavier Ramnik J RJ
Cell reports 20180701 4
Phagocyte microbiocidal mechanisms and inflammatory cytokine production are temporally coordinated, although their respective interdependencies remain incompletely understood. Here, we identify a nitric-oxide-mediated antioxidant response as a negative feedback regulator of inflammatory cytokine production in phagocytes. In this context, Keap1 functions as a cellular redox sensor that responds to elevated reactive nitrogen intermediates by eliciting an adaptive transcriptional program controlled ...[more]