Ontology highlight
ABSTRACT:
SUBMITTER: Ochyl LJ
PROVIDER: S-EPMC6156795 | biostudies-literature | 2018 Nov
REPOSITORIES: biostudies-literature
Ochyl Lukasz J LJ Bazzill Joseph D JD Park Charles C Xu Yao Y Kuai Rui R Moon James J JJ
Biomaterials 20180809
Despite the promise and advantages of autologous cancer cell vaccination, it remains challenging to induce potent anti-tumor immune responses with traditional immunization strategies with whole tumor cell lysate. In this study, we sought to develop a simple and effective approach for therapeutic vaccination with autologous whole tumor cell lysate. Endogenous cell membranes harvested from cancer cells were formed into PEGylated nano-vesicles (PEG-NPs). PEG-NPs exhibited good serum stability in vi ...[more]