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Investigation of parent-of-origin effects induced by fenofibrate treatment on triglycerides levels.


ABSTRACT: BACKGROUND:Genome-wide association studies performed on triglycerides (TGs) have not accounted for epigenetic mechanisms that may partially explain trait heritability. RESULTS:Parent-of-origin (POO) effect association analyses using an agnostic approach or a candidate approach were performed for pretreatment TG levels, posttreatment TG levels, and pre- and posttreatment TG-level differences in the real GAW20 family data set. We detected 22 genetic variants with suggestive POO effects with at least 1 phenotype (P???10-?5). We evaluated the association of these 22 significant genetic variants showing POO effects with close DNA methylation probes associated with TGs. A total of 18 DNA methylation probes located in the vicinity of the 22 SNPs were associated with at least 1 phenotype and 6 SNP-probe pairs were associated with DNA methylation probes at the nominal level of P?

SUBMITTER: Sarnowski C 

PROVIDER: S-EPMC6156838 | biostudies-literature | 2018 Sep

REPOSITORIES: biostudies-literature

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Investigation of parent-of-origin effects induced by fenofibrate treatment on triglycerides levels.

Sarnowski Chloé C   Lent Samantha S   Dupuis Josée J  

BMC genetics 20180917 Suppl 1


<h4>Background</h4>Genome-wide association studies performed on triglycerides (TGs) have not accounted for epigenetic mechanisms that may partially explain trait heritability.<h4>Results</h4>Parent-of-origin (POO) effect association analyses using an agnostic approach or a candidate approach were performed for pretreatment TG levels, posttreatment TG levels, and pre- and posttreatment TG-level differences in the real GAW20 family data set. We detected 22 genetic variants with suggestive POO effe  ...[more]

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