Analysis of genetic and nongenetic factors influencing triglycerides-lowering drug effects based on paired observations.
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ABSTRACT:
SUBMITTER: Xu Z
PROVIDER: S-EPMC6157156 | biostudies-literature | 2018
REPOSITORIES: biostudies-literature
Publications
Analysis of genetic and nongenetic factors influencing triglycerides-lowering drug effects based on paired observations.
Xu Zheng Z Duan Qing Q Cui Juan J Qiu Yumou Y Jia Qidong Q Wu Cong C Clarke Jennifer J
BMC proceedings 20180917 Suppl 9
Obesity is a risk factor for heart disease, stroke, diabetes, high blood pressure, and other chronic diseases. Some drugs, including fenofibrate, are used to treat obesity or excessive weight by lowering the level of specific triglycerides. However, different groups have different drug sensitivities and, consequently, there are differences in drug effects. In this study, we assessed both genetic and nongenetic factors that influence drug responses and stratified patients into groups based on dif ...[more]
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