Unknown

Dataset Information

0

Iodine Intake is Associated with Thyroid Function in Mild to Moderately Iodine Deficient Pregnant Women.


ABSTRACT: BACKGROUND:Studies indicate that mild to moderate iodine deficiency in pregnancy may have a long-term negative impact on child neurodevelopment. These effects are likely mediated via changes in maternal thyroid function, since iodine is essential for the production of thyroid hormones. However, the impact of iodine availability on thyroid function during pregnancy and on thyroid function reference ranges are understudied. The aim of this study was to investigate the association between iodine intake and thyroid function during pregnancy. DESIGN:In a population-based pregnancy cohort including 2910 pregnant women participating in The Norwegian Mother and Child Cohort Study, we explored cross sectional associations of maternal iodine intake measured (1) by a food frequency questionnaire and (2) as iodine concentration in a spot urine sample, with plasma thyroid hormones and antibodies. RESULTS:Biological samples were collected in mean gestational week 18.5 (standard deviation 1.3) and diet was assessed in gestational week 22. Median iodine intake from food was 121??g/day (interquartile range 90, 160), and 40% reported use of iodine-containing supplements in pregnancy. Median urinary iodine concentration (UIC) was 59??g/L among those who did not use supplements and 98??g/L in the women reporting current use at the time of sampling, indicating mild to moderate iodine deficiency in both groups. Iodine intake as measured by the food frequency questionnaire was not associated with the outcome measures, while UIC was inversely associated with FT3 (p?=?0.002) and FT4 (p?

SUBMITTER: Abel MH 

PROVIDER: S-EPMC6157349 | biostudies-literature | 2018 Oct

REPOSITORIES: biostudies-literature

altmetric image

Publications

Iodine Intake is Associated with Thyroid Function in Mild to Moderately Iodine Deficient Pregnant Women.

Abel Marianne Hope MH   Korevaar Tim I M TIM   Erlund Iris I   Villanger Gro Dehli GD   Caspersen Ida Henriette IH   Arohonka Petra P   Alexander Jan J   Meltzer Helle Margrete HM   Brantsæter Anne Lise AL  

Thyroid : official journal of the American Thyroid Association 20181001 10


<h4>Background</h4>Studies indicate that mild to moderate iodine deficiency in pregnancy may have a long-term negative impact on child neurodevelopment. These effects are likely mediated via changes in maternal thyroid function, since iodine is essential for the production of thyroid hormones. However, the impact of iodine availability on thyroid function during pregnancy and on thyroid function reference ranges are understudied. The aim of this study was to investigate the association between i  ...[more]

Similar Datasets

| S-EPMC8485914 | biostudies-literature
| S-EPMC10460065 | biostudies-literature
| S-EPMC7573140 | biostudies-literature
| S-EPMC10097226 | biostudies-literature
| S-EPMC6860313 | biostudies-literature
| S-EPMC10261634 | biostudies-literature
| S-EPMC8419609 | biostudies-literature
| S-EPMC10665901 | biostudies-literature
| S-EPMC5004499 | biostudies-other
| S-EPMC7146631 | biostudies-literature