Dataset Information

Prevalence of depression in patients with type 2 diabetes mellitus in Spain (the DIADEMA Study) : results from the MADIABETES cohort.

ABSTRACT:

Objective

To estimate the prevalence of depression in patients diagnosed with type 2 diabetes mellitus (T2DM), and to identify sociodemographic, clinical and psychological factors associated with depression in this population. Additionally, we examine the annual incidence rate of depression among patients with T2DM.

Methods

We performed a large prospective cohort study of patients with T2DM from the Madrid Diabetes Study. The first recruitment drive included 3443 patients. The second recruitment drive included 727 new patients. Data have been collected since 2007 (baseline visit) and annually during the follow-up period (since 2008).

Results

Depression was prevalent in 20.03% of patients (n=592; 95%?CI 18.6% to 21.5%) and was associated with previous personal history of depression (OR 6.482; 95%?CI 5.138 to 8.178), mental health status below mean (OR 1.423; 95%?CI 1.452 to 2.577), neuropathy (OR 1.951; 95%?CI 1.423 to 2.674), fair or poor self-reported health status (OR 1.509; 95%?CI 1.209 to 1.882), treatment with oral antidiabetic agents plus insulin (OR 1.802; 95%?CI 1.364 to 2.380), female gender (OR 1.333; 95%?CI 1.009 to 1.761) and blood cholesterol level (OR 1.005; 95%?CI 1.002 to 1.009). The variables inversely associated with depression were: being in employment (OR 0.595; 95%?CI 0.397 to 0.894), low physical activity (OR 0.552; 95%?CI 0.408 to 0.746), systolic blood pressure (OR 0.982; 95%?CI 0.971 to 0.992) and social support (OR 0.978; 95%?CI 0.963 to 0.993). In patients without depression at baseline, the incidence of depression after 1?year of follow-up was 1.20% (95% CI 1.11% to 2.81%).

Conclusions

Depression is very prevalent among patients with T2DM and is associated with several key diabetes-related outcomes. Our results suggest that previous mental status, self-reported health status, gender and several diabetes-related complications are associated with differences in the degree of depression. These findings should alert practitioners to the importance of detecting depression in patients with T2DM.

SUBMITTER: Salinero-Fort MA

PROVIDER: S-EPMC6157517 | biostudies-literature | 2018 Sep

REPOSITORIES: biostudies-literature

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Publications

Prevalence of depression in patients with type 2 diabetes mellitus in Spain (the DIADEMA Study) : results from the MADIABETES cohort.

Salinero-Fort Miguel Angel MA Gómez-Campelo P P San Andrés-Rebollo F Javier FJ Cárdenas-Valladolid Juan J Abánades-Herranz Juan C JC Carrillo de Santa Pau Enrique E Chico-Moraleja Rosa M RM Beamud-Victoria Domingo D de Miguel-Yanes Jose M JM Jimenez-Garcia Rodrigo R López-de-Andres Ana A Ramallo-Fariña Yolanda Y De Burgos-Lunar Carmen C

BMJ open 20180924 9

<h4>Objective</h4>To estimate the prevalence of depression in patients diagnosed with type 2 diabetes mellitus (T2DM), and to identify sociodemographic, clinical and psychological factors associated with depression in this population. Additionally, we examine the annual incidence rate of depression among patients with T2DM.<h4>Methods</h4>We performed a large prospective cohort study of patients with T2DM from the Madrid Diabetes Study. The first recruitment drive included 3443 patients. The sec ...[more]

PMID: 30249627

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Project description:BackgroundIncreased risk of osteoporosis and its clinical significance in patients with diabetes is controversial. We analyze osteoporosis prevalence and determinants of bone mineral density (BMD) in patients with type 1 and 2 diabetes.MethodsThree hundred and ninety-eight consecutive diabetic patients from a single outpatient clinic received a standardized questionnaire on osteoporosis risk factors, and were evaluated for diabetes-related complications, HbA1c levels, and lumbar spine (LS) and femoral neck (FN) BMD. Of these, 139 (71 men, 68 women) type 1 and 243 (115 men, 128 women) type 2 diabetes patients were included in the study. BMD (T-scores and values adjusted for age, BMI and duration of disease) was compared between patient groups and between patients with type 2 diabetes and population-based controls (255 men, 249 women).ResultsFor both genders, adjusted BMD was not different between the type 1 and type 2 diabetes groups but was higher in the type 2 group compared with controls (p?<?0.0001). Osteoporosis prevalence (BMD T-score?<?-2.5 SD) at FN and LS was equivalent in the type 1 and type 2 diabetes groups, but lower in type 2 patients compared with controls (FN: 13.0% vs 21.2%, LS: 6.1% vs 14.9% men; FN: 21.9% vs 32.1%, LS: 9.4% vs 26.9% women). Osteoporosis prevalence was higher at FN-BMD than at LS-BMD. BMD was positively correlated with BMI and negatively correlated with age, but not correlated with diabetes-specific parameters (therapy, HbBA1c, micro- and macrovascular complications) in all subgroups. Fragility fracture prevalence was low (5.2%) and not different between diabetes groups. Fracture patients had lower BMDs compared with those without fractures; however, BMD T-score was above -2.5 SD in most patients.ConclusionsDiabetes-specific parameters did not predict BMD. Fracture occurrence was similar in both diabetes groups and related to lower BMD, but seems unrelated to the threshold T-score, <-2.5 SD. These results suggest that osteoporosis, and related fractures, is a clinically significant and commonly underestimated problem in diabetes patients.

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Dataset Information

Prevalence of depression in patients with type 2 diabetes mellitus in Spain (the DIADEMA Study) : results from the MADIABETES cohort.

Objective

Methods

Results

Conclusions

Publications

Prevalence of depression in patients with type 2 diabetes mellitus in Spain (the DIADEMA Study) : results from the MADIABETES cohort.

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