Ontology highlight
ABSTRACT:
SUBMITTER: Furukawa H
PROVIDER: S-EPMC6157818 | biostudies-literature | 2018
REPOSITORIES: biostudies-literature
Furukawa Hiroshi H Oka Shomi S Shimada Kota K Hashimoto Atsushi A Komiya Akiko A Tsunoda Shinichiro S Suda Akiko A Ito Satoshi S Saisho Koichiro K Katayama Masao M Shinohara Satoshi S Sato Takeo T Nagatani Katsuya K Minota Seiji S Matsui Toshihiro T Fukui Naoshi N Sugii Shoji S Sano Hajime H Migita Kiyoshi K Nagaoka Shouhei S Tohma Shigeto S
PloS one 20180920 9
<h4>Objective</h4>Rheumatoid arthritis (RA) is a chronic autoimmune disease characterized with joint destructions; environmental and genetic factors were thought to be involved in the etiology of RA. The production of anti-citrullinated peptide antibodies (ACPA) is specifically associated with RA. DRB1 is associated with the susceptibility of RA, especially ACPA-positive RA [ACPA(+)RA]. However, a few studies reported on the independent associations of DPB1 alleles with RA susceptibility. Thus, ...[more]