Association of IFN?4 rs12979860 polymorphism with the acquisition of HCV and HIV infections among people who inject drugs.
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ABSTRACT:
SUBMITTER: Jogeda EL
PROVIDER: S-EPMC6158102 | biostudies-literature | 2018 Nov
REPOSITORIES: biostudies-literature
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Association of IFNλ4 rs12979860 polymorphism with the acquisition of HCV and HIV infections among people who inject drugs.
Jõgeda Ene-Ly EL Avi Radko R Pauskar Merit M Kallas Eveli E Karki Tõnis T Des Jarlais Don D Uusküla Anneli A Toompere Karolin K Lutsar Irja I Huik Kristi K
Journal of medical virology 20180816 11
We investigated the presence of a single-nucleotide polymorphism designated rs12979860 in the interferon λ4 (IFNλ4) gene among 345 people who inject drugs (PWID) and 495 blood donors to evaluate associations between the rs12979860 genotypes and human immunodeficiency virus/hepatitis C virus (HIV/HCV). The rs12979860 TT genotype was over-represented among HIV+ PWID than HIV- PWID and blood donors (16% vs 8% and 10%, P = 0.03, respectively). PWID with TT genotype had approximately twice the probab ...[more]
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