Ontology highlight
ABSTRACT:
SUBMITTER: Genova RM
PROVIDER: S-EPMC6158251 | biostudies-literature | 2018 Sep
REPOSITORIES: biostudies-literature
Genova Rachel M RM Meyer Kacie J KJ Anderson Michael G MG Harper Matthew M MM Pieper Andrew A AA
Scientific reports 20180926 1
Neprilysin (NEP), an ectoenzyme that modulates inflammation by degrading neuropeptides, was recently identified in the human corneal epithelium. The cornea expresses many NEP substrates, but the function of NEP in homeostatic maintenance and wound healing of the cornea is unknown. We therefore investigated the role of this enzyme under naive and injured conditions using NEP-deficient (NEP<sup>-/-</sup>) and wild type (WT) control mice. In vivo ocular surface imaging and histological analysis of ...[more]