Ontology highlight
ABSTRACT:
SUBMITTER: Worst TS
PROVIDER: S-EPMC6158275 | biostudies-literature | 2018 Sep
REPOSITORIES: biostudies-literature
Worst Thomas S TS Weis Cleo-Aron CA Stöhr Robert R Bertz Simone S Eckstein Markus M Otto Wolfgang W Breyer Johannes J Hartmann Arndt A Bolenz Christian C Wirtz Ralph M RM Erben Philipp P
Scientific reports 20180926 1
Deletions of the cell cycle control gene CDKN2A are described as progression markers of non-muscle invasive bladder cancer and to be associated with fibroblast growth factor 3 (FGFR3) mutations. The prognostic role of CDKN2A RNA expression in muscle invasive bladder cancer (MIBC) is under discussion. In 80 MIBC patients (m/f 60/20) who underwent radical cystectomy the expression of CDKN2A and FGFR3 was examined with qRT-PCR (test cohort). The MDA cohort (n = 57) and the TCGA cohort (n = 365) ser ...[more]