Ontology highlight
ABSTRACT:
SUBMITTER: Ogmundsdottir MH
PROVIDER: S-EPMC6158294 | biostudies-literature | 2018 Sep
REPOSITORIES: biostudies-literature
Scientific reports 20180926 1
Autophagy is a degradation pathway important for cellular homeostasis. The E1-like enzyme ATG7 is a key component of the autophagy machinery, with the main function of mediating the lipidation of LC3/GABARAP during autophagosome formation. By analysing mRNA-sequencing data we found that in addition to the full-length ATG7 isoform, various tissues express a shorter isoform lacking an exon of 27 amino acids in the C-terminal part of the protein, termed ATG7(2). We further show that ATG7(2) does no ...[more]