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The conserved regulatory RNA RsaE down-regulates the arginine degradation pathway in Staphylococcus aureus.


ABSTRACT: RsaE is a regulatory RNA highly conserved amongst Firmicutes that lowers the amount of mRNAs associated with the TCA cycle and folate metabolism. A search for new RsaE targets in Staphylococcus aureus revealed that in addition to previously described substrates, RsaE down-regulates several genes associated with arginine catabolism. In particular, RsaE targets the arginase rocF mRNA via direct interactions involving G-rich motifs. Two duplicated C-rich motifs of RsaE can independently downregulate rocF expression. The faster growth rate of ?rsaE compared to its parental strain in media containing amino acids as sole carbon source points to an underlying role for RsaE in amino acid catabolism. Collectively, the data support a model in which RsaE acts as a global regulator of functions associated with metabolic adaptation.

SUBMITTER: Rochat T 

PROVIDER: S-EPMC6158497 | biostudies-literature | 2018 Sep

REPOSITORIES: biostudies-literature

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The conserved regulatory RNA RsaE down-regulates the arginine degradation pathway in Staphylococcus aureus.

Rochat Tatiana T   Bohn Chantal C   Morvan Claire C   Le Lam Thao Nguyen TN   Razvi Fareha F   Pain Adrien A   Toffano-Nioche Claire C   Ponien Prishila P   Jacq Annick A   Jacquet Eric E   Fey Paul D PD   Gautheret Daniel D   Bouloc Philippe P  

Nucleic acids research 20180901 17


RsaE is a regulatory RNA highly conserved amongst Firmicutes that lowers the amount of mRNAs associated with the TCA cycle and folate metabolism. A search for new RsaE targets in Staphylococcus aureus revealed that in addition to previously described substrates, RsaE down-regulates several genes associated with arginine catabolism. In particular, RsaE targets the arginase rocF mRNA via direct interactions involving G-rich motifs. Two duplicated C-rich motifs of RsaE can independently downregulat  ...[more]

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