Ontology highlight
ABSTRACT:
SUBMITTER: Girardot M
PROVIDER: S-EPMC6158501 | biostudies-literature | 2018 Sep
REPOSITORIES: biostudies-literature
Girardot Michael M Bayet Elsa E Maurin Justine J Fort Philippe P Roux Pierre P Raynaud Peggy P
Nucleic acids research 20180901 17
SOX9 is known as a crucial transcription factor for various developmental processes and for tissue homeostasis. We examined here its potential role in alternative splicing by analyzing global splicing changes, using RNA-seq of colon tumor cells. We show that SOX9 knockdown alters the splicing of hundreds of genes without affecting their expression levels, revealing that SOX9 controls distinct splicing and transcriptional programs. SOX9 does not affect splicing patterns through the control of spl ...[more]