Dataset Information

Discovery of two-level modular organization from matched genomic data via joint matrix tri-factorization.

ABSTRACT: With the rapid development of biotechnology, multi-dimensional genomic data are available for us to study the regulatory associations among multiple levels. Thus, it is essential to develop a tool to identify not only the modular patterns from multiple levels, but also the relationships among these modules. In this study, we adopt a novel non-negative matrix factorization framework (NetNMF) to integrate pairwise genomic data in a network manner. NetNMF could reveal the modules of each dimension and the connections within and between both types of modules. We first demonstrated the effectiveness of NetNMF using a set of simulated data and compared it with two typical NMF methods. Further, we applied it to two different types of pairwise genomic datasets including microRNA (miRNA) and gene expression data from The Cancer Genome Atlas and gene expression and pharmacological data from the Cancer Genome Project. We respectively identified a two-level miRNA-gene module network and a two-level gene-drug module network. Not only have the majority of identified modules significantly functional implications, but also the three types of module pairs have closely biological associations. This module discovery tool provides us comprehensive insights into the mechanisms of how the two levels of molecules cooperate with each other.

SUBMITTER: Chen J

PROVIDER: S-EPMC6158745 | biostudies-literature | 2018 Jul

REPOSITORIES: biostudies-literature

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Discovery of two-level modular organization from matched genomic data via joint matrix tri-factorization.

Chen Jinyu J Zhang Shihua S

Nucleic acids research 20180701 12

With the rapid development of biotechnology, multi-dimensional genomic data are available for us to study the regulatory associations among multiple levels. Thus, it is essential to develop a tool to identify not only the modular patterns from multiple levels, but also the relationships among these modules. In this study, we adopt a novel non-negative matrix factorization framework (NetNMF) to integrate pairwise genomic data in a network manner. NetNMF could reveal the modules of each dimension ...[more]

PMID: 29878151

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Project description:Background:Matrix factorization is a well established pattern discovery tool that has seen numerous applications in biomedical data analytics, such as gene expression co-clustering, patient stratification, and gene-disease association mining. Matrix factorization learns a latent data model that takes a data matrix and transforms it into a latent feature space enabling generalization, noise removal and feature discovery. However, factorization algorithms are numerically intensive, and hence there is a pressing challenge to scale current algorithms to work with large datasets. Our focus in this paper is matrix tri-factorization, a popular method that is not limited by the assumption of standard matrix factorization about data residing in one latent space. Matrix tri-factorization solves this by inferring a separate latent space for each dimension in a data matrix, and a latent mapping of interactions between the inferred spaces, making the approach particularly suitable for biomedical data mining. Results:We developed a block-wise approach for latent factor learning in matrix tri-factorization. The approach partitions a data matrix into disjoint submatrices that are treated independently and fed into a parallel factorization system. An appealing property of the proposed approach is its mathematical equivalence with serial matrix tri-factorization. In a study on large biomedical datasets we show that our approach scales well on multi-processor and multi-GPU architectures. On a four-GPU system we demonstrate that our approach can be more than 100-times faster than its single-processor counterpart. Conclusions:A general approach for scaling non-negative matrix tri-factorization is proposed. The approach is especially useful parallel matrix factorization implemented in a multi-GPU environment. We expect the new approach will be useful in emerging procedures for latent factor analysis, notably for data integration, where many large data matrices need to be collectively factorized.

Dataset Information

Discovery of two-level modular organization from matched genomic data via joint matrix tri-factorization.

Publications

Discovery of two-level modular organization from matched genomic data via joint matrix tri-factorization.

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