Ontology highlight
ABSTRACT:
SUBMITTER: Cheng L
PROVIDER: S-EPMC6159955 | biostudies-literature | 2018 Oct
REPOSITORIES: biostudies-literature
Cheng Liang L Wang Qi Q Li Guangming G Banga Riddhima R Ma Jianping J Yu Haisheng H Yasui Fumihiko F Zhang Zheng Z Pantaleo Giuseppe G Perreau Matthieu M Zurawski Sandra S Zurawski Gerard G Levy Yves Y Su Lishan L
The Journal of clinical investigation 20180827 10
Activation of HIV-1 reservoirs and induction of anti-HIV-1 T cells are critical to control HIV-1 rebound after combined antiretroviral therapy (cART). Here we evaluated in humanized mice (hu-mice) with persistent HIV-1 infection the therapeutic effect of TLR3 agonist and a CD40-targeting HIV-1 vaccine, which consists of a string of 5 highly conserved CD4+ and CD8+ T cell epitope-rich regions of HIV-1 Gag, Nef, and Pol fused to the C-terminus of a recombinant anti-human CD40 antibody (αCD40.HIV5p ...[more]