Ontology highlight
ABSTRACT:
SUBMITTER: Li L
PROVIDER: S-EPMC6160000 | biostudies-literature | 2018 Oct
REPOSITORIES: biostudies-literature
Li Li L Guturi Kiran Kumar Naidu KKN Gautreau Brandon B Patel Parasvi S PS Saad Amine A Morii Mayako M Mateo Francesca F Palomero Luis L Barbour Haithem H Gomez Antonio A Ng Deborah D Kotlyar Max M Pastrello Chiara C Jackson Hartland W HW Khokha Rama R Jurisica Igor I Affar El Bachir EB Raught Brian B Sanchez Otto O Alaoui-Jamali Moulay M Pujana Miguel A MA Hakem Anne A Hakem Razq R
The Journal of clinical investigation 20180802 10
The E3 ubiquitin ligase RNF8 plays critical roles in maintaining genomic stability by promoting the repair of DNA double-strand breaks (DSBs) through ubiquitin signaling. Abnormal activation of Notch signaling and defective repair of DSBs promote breast cancer risk. Here, we found that low expression of the full-length RNF8 correlated with poor prognosis for breast cancer patients. Our data revealed that in addition to its role in the repair of DSBs, RNF8 regulated Notch1 signaling and cell-fate ...[more]