Dataset Information

Asthma is associated with carotid arterial injury in children: The Childhood Origins of Asthma (COAST) Cohort.

ABSTRACT:

Background

Asthma is associated with an increased cardiovascular disease (CVD) risk in adults, but the impact of asthma and atopic conditions on CVD risk in children is less well established. We hypothesized that children in the Childhood Origins of Asthma (COAST) Cohort with asthma and atopic conditions would have early carotid arterial injury.

Methods

The COAST study is a longitudinal birth cohort of children at increased risk of developing asthma. Children underwent ultrasonography measuring far wall right carotid bifurcation (RCB) and common carotid artery (RCCA) intima-media thickness (IMT; a measure of arterial injury). Multivariable linear regression models adjusted for age, gender, race, blood pressure, and body-mass index were used to assess associations of asthma and markers of arterial injury.

Results

The 89 participants were a mean (standard deviation) 15.3 (0.6) years old and 42% were female; 28 asthmatics had atopic disease, 34 asthmatics were without other atopic disease, and 15 non-asthmatics had atopic disease. This study population was compared to 12 controls (participants free of asthma or atopic disease). Compared to controls (589 ?m), those with atopic disease (653 ?m, p = 0.07), asthma (649 ?m, p = 0.05), or both (677 ?m, p = 0.005) had progressively higher RCB IMT values (ptrend = 0.011). In adjusted models, asthmatic and/or atopic participants had significantly higher RCB IMT than those without asthma or atopic disease (all p?0.03). Similar relationships were found for RCCA IMT.

Conclusion

Adolescents with asthma and other atopic diseases have an increased risk of subclinical arterial injury compared to children without asthma or other atopic disease.

SUBMITTER: Tattersall MC

PROVIDER: S-EPMC6160166 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature

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Publications

Asthma is associated with carotid arterial injury in children: The Childhood Origins of Asthma (COAST) Cohort.

Tattersall Matthew C MC Evans Michael D MD Korcarz Claudia E CE Mitchell Carol C Anderson Elizabeth E DaSilva Douglas F DF Salazar Lisa P LP Gern James E JE Jackson Daniel J DJ Lemanske Robert F RF Stein James H JH

PloS one 20180927 9

<h4>Background</h4>Asthma is associated with an increased cardiovascular disease (CVD) risk in adults, but the impact of asthma and atopic conditions on CVD risk in children is less well established. We hypothesized that children in the Childhood Origins of Asthma (COAST) Cohort with asthma and atopic conditions would have early carotid arterial injury.<h4>Methods</h4>The COAST study is a longitudinal birth cohort of children at increased risk of developing asthma. Children underwent ultrasonogr ...[more]

PMID: 30261051

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Project description:BackgroundChildhood food insecurity has been associated with prevalent asthma in cross-sectional studies. Little is known about the relationship between food insecurity and incident asthma.MethodsWe used administrative databases linked with the Canadian Community Health Survey, to conduct a retrospective cohort study of children <18 years in Ontario, Canada. Children without a previous diagnosis of asthma who had a household response to the Household Food Security Survey Module (HFSSM) were followed until March 31, 2018 for new asthma diagnoses using a validated administrative coding algorithm. We used multivariable Cox proportional hazard models to examine the association between food insecurity and incident asthma, and adjusted models sequentially for clinical and clinical/socioeconomic risk factors. As additional analyses, we examined associations by HFSSM respondent type, severity of food insecurity, and age of asthma diagnosis. Moreover, we assessed for interaction between food security and child's sex, household smoking status, and maternal asthma on the risk of incident asthma.ResultsAmong the 27,746 included children, 5.1% lived in food insecure households. Over a median of 8.34 years, the incidence of asthma was 7.33/1000 person-years (PY) among food insecure children and 5.91/1000 PY among food secure children (unadjusted hazard ratio [HR] 1.24, 95% CI 1.00 to 1.54, p = 0.051). In adjusted analyses associations were similar (HR 1.16, 95% CI 0.91 to 1.47, p = 0.24 adjusted for clinical risk factors, HR 1.24, 95% CI 0.97 to 1.60, p = 0.09 adjusted for clinical/socioeconomic factors). Associations did not qualitatively change by HFSSM respondent type, severity of food insecurity, and age of asthma diagnosis. There was no evidence of interaction in our models.ConclusionsFood insecure children have numerous medical and social challenges. However, in this large population-based study, we did not observe that childhood food insecurity was associated with an increased risk of incident asthma when adjusted for important clinical and socioeconomic confounders.

Dataset Information

Asthma is associated with carotid arterial injury in children: The Childhood Origins of Asthma (COAST) Cohort.

Background

Methods

Results

Conclusion

Publications

Asthma is associated with carotid arterial injury in children: The Childhood Origins of Asthma (COAST) Cohort.

Similar Datasets

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