Dataset Information

Exploring 3-hinge gyral folding patterns among HCP Q3 868 human subjects.

ABSTRACT: Comparison and integration of neuroimaging data from different brains and populations are fundamental in neuroscience. Over the past decades, the neuroimaging field has largely depended on image registration to compare and integrate neuroimaging data from individuals in a common reference space, with a basic assumption that the brains are similar. However, the intrinsic neuroanatomical complexity and huge interindividual cortical folding variation remain underexplored. Here we focus on a specific cortical convolution pattern, termed 3-hinge gyral folding, which is the conjunction of gyri from multiple orientations and has unique and consistent anatomically, structurally, and functionally connective patterns across subjects. By developing a novel shape descriptor and a two-stage clustering pipeline, we devise an automatic method to identify 3-hinges in the Human Connectome Project Q3 868 human brains, and further parameterize the complexity of such a pattern and quantify its regularity and variation in terms of 3-hinge number, position, and morphology. Our results not only exhibit the huge interindividual variations, but also reveal regular relationship between gyral hinges and other factors, such as their locations and cortical morphologies. It is found that "line-shape" cortices have relatively more consistent 3-hinge shape pattern distributions, and certain types of 3-hinge patterns favor particular cortical morphologies. In addition, more 3-hinges are found on "line-shape" cortices while their numbers vary more across subjects than those on "non-line-shape" cortices. This study adds new insights into a better understanding of the regularity and variability of human brain anatomy, and their functional aspects.

SUBMITTER: Zhang T

PROVIDER: S-EPMC6160316 | biostudies-literature |

REPOSITORIES: biostudies-literature

ACCESS DATA

Similar Datasets

Project description:The highly convoluted cortical folding of the human brain is intriguingly complex and variable across individuals. Exploring the underlying representative patterns of cortical folding is of great importance for many neuroimaging studies. At term birth, all major cortical folds are established and are minimally affected by the complicated postnatal environments; hence, neonates are the ideal candidates for exploring early postnatal cortical folding patterns, which yet remain largely unexplored. In this paper, we propose a novel method for exploring the representative regional folding patterns of infant brains. Specifically, first, multi-view curvature features are constructed to comprehensively characterize the complex characteristics of cortical folding. Second, for each view of curvature features, a similarity matrix is computed to measure the similarity of cortical folding in a specific region between any pair of subjects. Next, a similarity network fusion method is adopted to nonlinearly and adaptively fuse all the similarity matrices into a single one for retaining both shared and complementary similarity information of the multiple characteristics of cortical folding. Finally, based on the fused similarity matrix and a hierarchical affinity propagation clustering approach, all subjects are automatically grouped into several clusters to obtain the representative folding patterns. To show the applications, we have applied the proposed method to a large-scale dataset with 595 normal neonates and discovered representative folding patterns in several cortical regions, i.e., the superior temporal gyrus (STG), inferior frontal gyrus (IFG), precuneus, and cingulate cortex. Meanwhile, we have revealed sex difference in STG, IFG, and cingulate cortex, as well as hemispheric asymmetries in STG and cingulate cortex in terms of cortical folding patterns. Moreover, we have also validated the proposed method on a public adult dataset, i.e., the Human Connectome Project (HCP), and revealed that certain major cortical folding patterns of adults are largely established at term birth.

Dataset Information

Exploring 3-hinge gyral folding patterns among HCP Q3 868 human subjects.

Similar Datasets

OmicsDI is part of the ELIXIR infrastructure

Tweets