Ontology highlight
ABSTRACT:
SUBMITTER: Xu C
PROVIDER: S-EPMC6160330 | biostudies-literature | 2018 Sep
REPOSITORIES: biostudies-literature
Xu Chengyun C Zou Chaochun C Hussain Musaddique M Shi Wei W Shao Yanan Y Jiang Ziyan Z Wu Xiling X Lu Meiping M Wu Junsong J Xie Qiangmin Q Ke Yuehai Y Long Fanxin F Tang Lanfang L Wu Ximei X
Mucosal immunology 20180604 5
Sonic hedgehog (SHH) is abundantly expressed and critical for morphogenesis in embryonic lungs; however, SHH expression drops to a much lower level in mice from E17.5 and in humans from the 21st gestational week. We find that SHH expression is robustly upregulated in the airway epithelia of children with asthma or mouse models with allergic airway disease. Specifically, airway-specific SMO loss of function significantly suppresses allergen-induced goblet cell phenotypes, whereas an airway-specif ...[more]