Ontology highlight
ABSTRACT:
SUBMITTER: O'Shea MK
PROVIDER: S-EPMC6160428 | biostudies-literature | 2018 Sep
REPOSITORIES: biostudies-literature
O'Shea Matthew K MK Tanner Rachel R Müller Julius J Harris Stephanie A SA Wright Danny D Stockdale Lisa L Stylianou Elena E Satti Iman I Smith Steven G SG Dunbar James J Fletcher Thomas E TE Dedicoat Martin M Cunningham Adam F AF McShane Helen H
Scientific reports 20180927 1
A major contribution to the burden of Tuberculosis (TB) comes from latent Mycobacterium tuberculosis infections (LTBI) becoming clinically active. TB and LTBI probably exist as a spectrum and currently there are no correlates available to identify individuals with LTBI most at risk of developing active disease. We set out to identify immune parameters associated with ex vivo mycobacterial growth control among individuals with active TB disease or LTBI to define the spectrum of TB infection. We u ...[more]