Fasting-dependent Vascular Permeability Enhancement in Brown Adipose Tissues Evidenced by Using Carbon Nanotubes as Fluorescent Probes.

ABSTRACT: Brown adipose tissue (BAT), which is composed of thermogenic brown adipocytes (BA) and non-parenchymal components including vasculatures and extracellular matrix, contribute to the maintenance of body temperature. BAT distribution is detected by positron emission tomography-computed tomography (PET/CT) using ¹⁸F-fluorodeoxy glucose (¹⁸F-FDG) or single-photon-emission computed tomography-computed tomography (SPECT/CT) using [¹²³/¹²⁵I]-beta-methyl-p-iodophenyl-pentadecanoic acid. Although sympathetic nerve activity and thermogenic capacity of BA is downregulated under fasting conditions in mice, fasting-dependent structural changes and fluid kinetics of BAT remain unknown. Here we show that the fasting induces fine and reversible structural changes

SUBMITTER: Yudasaka M 

PROVIDER: S-EPMC6160465 | biostudies-literature | 2018 Sep

REPOSITORIES: biostudies-literature