Dataset Information

Patient-reported and performance-based measures of walking in mild-moderate Parkinson's disease.

ABSTRACT:

Background

Knowledge of the relationships between patient-reported and performance-based walking measures in Parkinson's disease (PD) should inform clinical decision-making. The Walk-12G reliably captures perceived walking difficulties but has not been compared to performance-based walking in laboratory or free-living settings or across different groups.

Objectives

To investigate the relationship between patient-reported walking difficulties (Walk-12G) and performance-based walking in laboratory and free-living conditions and to determine whether the Walk-12G can distinguish between the subgroups, (i) people with/without PD and (ii) mild/moderate disease stages.

Methods

Forty-seven people without and 49 people with PD (Hoehn and Yahr stage II and III) were assessed in relation to patient-reported walking difficulties (Walk-12G scale); spatiotemporal gait characteristics (Pace; Rhythm; Asymmetry; Variability; and Postural control) using a laboratory-based electronic walkway; and walking behavior (mean steps/day and minutes of brisk walking/day) using accelerometers in free-living conditions.

Results

The Walk-12G correlated moderately with the spatiotemporal domain step velocity (r = -0.46) and walking behavior, measured as mean steps/day (r = -0.46). Weaker correlations were observed for step length and minutes spent in brisk walking (r = -0.36 and r = -0.35, respectively). Poor correlations were observed for all other spatiotemporal domains. The Walk-12G could distinguish between people with and without PD (Effect size, r = 0.82) and between those at mild/moderate disease stages (r = 0.34).

Conclusions

Perceived walking difficulties showed weak to moderate associations with performance-based measures of walking in mild-moderate PD. As the strongest associations were observed for step velocity and walking behavior, targeting these specific gait aspects could improve perceived walking difficulties in daily life.

SUBMITTER: Leavy B

PROVIDER: S-EPMC6160642 | biostudies-literature | 2018 Sep

REPOSITORIES: biostudies-literature

ACCESS DATA

Publications

Patient-reported and performance-based measures of walking in mild-moderate Parkinson's disease.

Leavy Breiffni B Löfgren Niklas N Nilsson Maria M Franzén Erika E

Brain and behavior 20180822 9

<h4>Background</h4>Knowledge of the relationships between patient-reported and performance-based walking measures in Parkinson's disease (PD) should inform clinical decision-making. The Walk-12G reliably captures perceived walking difficulties but has not been compared to performance-based walking in laboratory or free-living settings or across different groups.<h4>Objectives</h4>To investigate the relationship between patient-reported walking difficulties (Walk-12G) and performance-based walkin ...[more]

PMID: 30136397

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Dataset Information

Patient-reported and performance-based measures of walking in mild-moderate Parkinson's disease.

Background

Objectives

Methods

Results

Conclusions

Publications

Patient-reported and performance-based measures of walking in mild-moderate Parkinson's disease.

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