Ontology highlight
ABSTRACT:
SUBMITTER: Goncalves CS
PROVIDER: S-EPMC6160775 | biostudies-literature | 2018
REPOSITORIES: biostudies-literature
Gonçalves Céline S CS Vieira de Castro Joana J Pojo Marta M Martins Eduarda P EP Queirós Sandro S Chautard Emmanuel E Taipa Ricardo R Pires Manuel Melo MM Pinto Afonso A AA Pardal Fernando F Custódia Carlos C Faria Cláudia C CC Clara Carlos C Reis Rui M RM Sousa Nuno N Costa Bruno M BM
Theranostics 20180909 17
Glioblastoma (GBM) is a universally fatal brain cancer, for which novel therapies targeting specific underlying oncogenic events are urgently needed. While the WNT pathway has been shown to be frequently activated in GBM, constituting a potential therapeutic target, the relevance of WNT6, an activator of this pathway, remains unknown. <b>Methods:</b> WNT6 protein and mRNA levels were evaluated in GBM. WNT6 levels were silenced or overexpressed in GBM cells to assess functional effects <i>in vitr ...[more]