Ontology highlight
ABSTRACT:
SUBMITTER: Liu H
PROVIDER: S-EPMC6161299 | biostudies-literature | 2018 Jul
REPOSITORIES: biostudies-literature
Liu Hui H Wang Jingjing J Li Wenchao W Hu Jie J Wang Min M Kang Yuejun Y
Pharmaceutics 20180719 3
Understanding of the interaction between cells and nanoparticles (NPs) is critical. Despite numerous attempts to understand the effect of several parameters of NPs on their cellular uptake behaviors, such as size, shape, surface chemistry, etc., limited information is available regarding NP rigidity. Herein, we investigate the effect of rigidity on cellular uptake behaviors of NPs, using generation 5 poly(amidoamine) dendrimer as a model. By harnessing the abundant inner cavity, their rigidity c ...[more]