Ontology highlight
ABSTRACT:
SUBMITTER: Brelstaff J
PROVIDER: S-EPMC6161320 | biostudies-literature | 2018 Aug
REPOSITORIES: biostudies-literature
Cell reports 20180801 8
Tau protein forms insoluble filamentous inclusions that are closely associated with nerve cell death in many neurodegenerative diseases. How neurons die in these tauopathies is unclear. We report that living neurons with tau inclusions from P301S-tau mice expose abnormally high amounts of phosphatidylserine because of the production of reactive oxygen species (ROS). Consequently, co-cultured phagocytes (BV2 cells or primary microglia) identify and phagocytose the living neurons, thereby engulfin ...[more]