Dataset Information

Fremanezumab for preventive treatment of migraine: Functional status on headache-free days.

ABSTRACT:

Objective

To evaluate the effect of fremanezumab on the functional status on headache-free days in phase 2 episodic migraine (EM) and chronic migraine (CM) studies.

Methods

Functional status data were collected prospectively via the electronic headache diary on all headache-free days by patients answering questions regarding work/school/household chore performance, speed of work completion, concentration, and feeling of fatigue. Individuals with EM receiving monthly doses of fremanezumab 225 mg (n = 96) or 675 mg (n = 97) or placebo (n = 104) were compared. Individuals with CM receiving fremanezumab 675 mg followed by monthly 225 mg (n = 88) and 900 mg (n = 86) were also independently compared to those receiving placebo (n = 89).

Results

In patients with EM, compared to patients receiving placebo, those receiving fremanezumab experienced an increased number of headache-free days with normal function in work/school/household chore performance and concentration/mental fatigue measures compared to their baseline over the entire treatment period (all p < 0.005). An increased number of headache-free days with normal functional performance for some measures was also found in the CM group in those treated with fremanezumab.

Conclusion

There was an increased number of headache-free days with normal functional performance on all measures for the patients with EM and some measures for patients with CM in the fremanezumab-treated groups. Further research is required to confirm these findings in a prospective study and to clarify the underlying mechanism(s).

Clinicaltrialsgov identifier

NCT02025556 and NCT02021773.

Classification of evidence

This study provides Class II evidence that for patients with migraine, fremanezumab increases normal functional performance on headache-free days.

SUBMITTER: VanderPluym J

PROVIDER: S-EPMC6161555 | biostudies-literature | 2018 Sep

REPOSITORIES: biostudies-literature

ACCESS DATA

Publications

Fremanezumab for preventive treatment of migraine: Functional status on headache-free days.

VanderPluym Juliana J Dodick David W DW Lipton Richard B RB Ma Yuju Y Loupe Pippa S PS Bigal Marcelo E ME

Neurology 20180817 12

<h4>Objective</h4>To evaluate the effect of fremanezumab on the functional status on headache-free days in phase 2 episodic migraine (EM) and chronic migraine (CM) studies.<h4>Methods</h4>Functional status data were collected prospectively via the electronic headache diary on all headache-free days by patients answering questions regarding work/school/household chore performance, speed of work completion, concentration, and feeling of fatigue. Individuals with EM receiving monthly doses of frema ...[more]

PMID: 30120138

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Dataset Information

Fremanezumab for preventive treatment of migraine: Functional status on headache-free days.

Objective

Methods

Results

Conclusion

Clinicaltrialsgov identifier

Classification of evidence

Publications

Fremanezumab for preventive treatment of migraine: Functional status on headache-free days.

Similar Datasets

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