Ontology highlight
ABSTRACT:
SUBMITTER: Izumikawa K
PROVIDER: S-EPMC6161726 | biostudies-literature | 2018
REPOSITORIES: biostudies-literature
Izumikawa Keiichi K Ishikawa Hideaki H Simpson Richard J RJ Takahashi Nobuhiro N
RNA biology 20180511 7
Chtop binds competitively to the arginine methyltransferases PRMT1 and PRMT5, thereby promoting the asymmetric or symmetric methylation of arginine residues, respectively. In cooperation with PRMT1, Chtop activates transcription of certain gene groups, such as the estrogen-inducible genes in breast cancer cells, the 5-hydroxymethylcytosine-modified genes involved in glioblastomagenesis, or the Zbp-89-dependent genes in erythroleukemia cells. Chtop also represses expression of the fetal γ-globin ...[more]