Meta-analysis of the likelihood of FOXC2 expression in early- and late-stage tumors.

ABSTRACT:

Background

Aberrations in the expression of the transcription factor forkhead box C2 (FOXC2) have been linked to a number of malignancies. Here, we characterized the relationship between FOXC2 and cancer progression by conducting a meta-analysis of studies that reported the frequency of FOXC2 expression in tumors of different stages (T1, T2, T3, T4).

Methods

Relevant articles were retrieved from the Medline database by searching for the terms "FOXC2" and "cancer"; then, the retrieved articles were reviewed individually, and studies that were of multivariate cohort design, evaluated FOXC2 expression via immunohistochemical staining, and assessed the relationship between FOXC2 expression and cancer T-stage were included in our meta-analysis.

Results

Our search terms ide

SUBMITTER: Kume T 

PROVIDER: S-EPMC6161797 | biostudies-literature | 2018 Sep

REPOSITORIES: biostudies-literature