Ontology highlight
ABSTRACT:
SUBMITTER: Hensley-McBain T
PROVIDER: S-EPMC6162106 | biostudies-literature | 2018 Sep
REPOSITORIES: biostudies-literature
Hensley-McBain Tiffany T Berard Alicia R AR Manuzak Jennifer A JA Miller Charlene J CJ Zevin Alexander S AS Polacino Patricia P Gile Jillian J Agricola Brian B Cameron Mark M Hu Shiu-Lok SL Estes Jacob D JD Reeves R Keith RK Smedley Jeremy J Keele Brandon F BF Burgener Adam D AD Klatt Nichole R NR
Mucosal immunology 20180615 5
HIV and pathogenic SIV infection are characterized by mucosal dysfunction including epithelial barrier damage, loss of Th17 cells, neutrophil infiltration, and microbial translocation with accompanying inflammation. However, it is unclear how and when these contributing factors occur relative to one another. In order to determine whether any of these features initiates the cycle of damage, we longitudinally evaluated the kinetics of mucosal and systemic T-cell activation, microbial translocation ...[more]