Ontology highlight
ABSTRACT:
SUBMITTER: Letellier M
PROVIDER: S-EPMC6162332 | biostudies-literature | 2018 Sep
REPOSITORIES: biostudies-literature
Letellier Mathieu M Szíber Zsófia Z Chamma Ingrid I Saphy Camille C Papasideri Ioanna I Tessier Béatrice B Sainlos Matthieu M Czöndör Katalin K Thoumine Olivier O
Nature communications 20180928 1
To better understand the molecular mechanisms by which early neuronal connections mature into synapses, we examined the impact of neuroligin-1 (Nlg1) phosphorylation on synapse differentiation, focusing on a unique intracellular tyrosine (Y782), which differentially regulates Nlg1 binding to PSD-95 and gephyrin. By expressing Nlg1 point mutants (Y782A/F) in hippocampal neurons, we show using imaging and electrophysiology that Y782 modulates the recruitment of functional AMPA receptors (AMPARs). ...[more]